College and background
Born August 6, 1983 in Waynesville, Missouri, Mosley attended Waynesville High Schoo, where he earned All-State honors and was ranked among the top DT prospects by Rivals.com. Mosley was a three-time All-District selection posted 21.0 sacks and 267 tackles during his career, and recorded 97 tackles and 10 sacks as a senior. He also finished 3rd in the shot put at the Missouri state track meet as a senior. He then attended the University of Missouri. After being redshirted in 2001, he earned Freshman All-America honorable mention honors from College Football News in 2002. He played in every game with 5 starts at nose guard and posted 39 tackles, 3 sacks, 8 tackles for loss, and a forced fumble. He began his collegiate career with 3 tackles, and 2 tackles for loss at Illinois and had 8 tackles and added a sack and 2 tackles for loss vs. Colorado. He also recorded a season-high 9 tackles and made a sack and 3 tackles for loss at Texas A&M. In 2003, he earned 2nd-team All-Big 12 honors from the league's coaches and was named the team's Defensive Lineman of the Year. That season, he started 11 games at nose guard and ranked among the nation's leaders with 16 tackles for loss on the year. He also was 2nd on the team with 7 QB hurries and 6.0 sacks. In 2004, Mosley earned Associated Press 1st-team All-Big 12 honors and was named the team's Defensive Lineman of the Year. That year, he started all 11 games at RDT, and led a defense that finished 2nd in the conference and 14th nationally in total yardage allowed. He made 61 tackles, 6.5 sacks, 14 tackles for loss, as well as recovering 2 fumbles, forced another, and blocked a kick. Mosley started 27 of 36 games he played in during his 3 years with the Tigers. He recorded 167 tackles with 15.5 sacks, 38 tackles for loss, and 22 QB hurries. He was part of a defense in 2004 that ranked 2nd in the Big 12 and 14th nationally in total yardage allowed and was twice named the team's Defensive Lineman of the Year.
Before the JetsMinnesota Vikings in the sixth round (191st overall) in the 2005 NFL Draft. In his rookie year for Minnesota, Mosley accumulated 19 tackles, 3 sacks and 1 forced fumble while filling in for an injured Kevin Williams in the middle of the 2005 season.
As a Jet
Mosley, along with an undisclosed draft pick, was traded to the Jets on 31 August 2006 for backup quarterback Brooks Bollinger. He played in two of the first twelve games of the 2006 season, but played in the remaining 5 games, getting his first sack in his return to Minnesota. He also made one playoff appearance. He has also appeared in the first seven games of the 2007 season.
Mosley majored in hotel and restaurant management while attending Missouri. His father, Calvin Sr., Retired from the U.S. Army this past summer. Growing up in an army family, he lived in California, Kansas, Missouri, Kentucky and Germany. He has 1 sister, Michelle, and 2 brothers, William and Theo Hightower.